Roadmap

Proteome of the 18th Human Chromosome:
Gene Centric Identification of Transcripts, Proteins and Peptides
download Addendum to the Roadmap: HEALTH ASPECTS

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The Human Proteome Project is focused on the inventory of all human proteins and the revelation of interactions occurring between them. In its scale, this project is superior to the Human Genome Project formally finished in 2001. The basic problems that HPP is facing are: impossibility of detecting single molecules in biological material and a situational nature of a proteome, i.e. the dependence of protein composition on the time and type of tissue and cells. Due to the presence of single amino acid polymorphisms (SAP), alternative splicing (AS) and post-translational modifications (PTM), as part of a whole proteome, one might assume the availability of several million of various protein forms.

As of now, the road map of the project is prepared as the Russian national gene-centric initiative. Within the pilot phase there will be revealed the transcripts of the 18th chromosome in the liver cells and 286 proteins in the liver cells and blood plasma and, also, novel technologies will be developed: as such, a technology on the basis of coupling AFM and MS, analytical device with the usage of nanowire sensing element, cloud informational system with the personal supercomputers.

This is truly an excellent document and a major step forward for HPP. This document certainly represents to date the most mature and complete proposal for HPP and can serve as a template not only for all chromosome-based initiatives but also for integration with HUPO initiatives in general.
— Laura Beretta, HUPO Chr HPP Workgroup

Human Proteome Project (HPP) as seen around the world

Annotated version of the Roadmap
HUPO Human Proteome Project
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