Russian part of the International Project

Russian Federation participates in the international Project to integrate the achievements in Russian proteomics as identification of the subproteome coded by the 18th chromosome of human genome.

The problems to be solved by the Russian part of the Project are:

to estimate theoretically and experimentally the total number of human proteins, and to select the biomaterial sources for the research, such as\ blood plasma and liver;
to select the human 18th chromosome as a subject for research based on 2 criteria: (i) a small number of expressed proteins; and (ii) a presence of many significant SNPs (Single-nucleotide polymorphism) associated to diseases;
to identify the transcripts of 18th chromosome in the samples of choice by transcriptomics;
to identify the high-copied and medium-copied proteins of 18th human chromosome by conventional proteomics;
to catalogue naturally-occurred peptides encoded by 18th chromosome (peptidomics);
to make proteotyping proteins expressed from 18th human chromosome;
to study the individual proteome variability of healthy donors selected by medical experts.